Contact Lens Associated Bacterial Keratitis: Common Organisms, Antibiotic Therapy, and Global Resistance Trends: A Systematic Review

Introduction Contact lens wearing has been increased globally during recent decades, which is one of the main risk factors for developing microbial keratitis. Microbial keratitis a severe and dangerous condition that causes cornea inflammation. It can lead to corneal scarring perforation or even endophthalmitis visual loss if it remains untreated. Among bacterial, fungal, protozoal, viral agents cause keratitis, bacteria are most common cause. Therefore, in this study, we aim find causative bacteria, sensitivity, resistance antibiotics outcome antibiotic therapy contact lens-related bacterial Methods A systematic search was carried out PubMed/Medline, EMBASE, Web Science published studies medRxiv preprints up February 30, 2021, May 14, respectively. combination following keywords used: “Infection”, “Corneal infection”, “Keratitis”, “Microbial keratitis”, “Contact lens”, Also, used lenses” MeSH term. Lists references each selected article relevant review articles were hand-searched identify further studies. Results Twenty-six included. From 1991 2018, 2,916 episodes keratitis) CLMK(with 1,642 proven have reviewed these Studies conducted 17 countries with different geographical regions, four Iran, highest number among countries. According 20 studies, mean age patients 30.77 years. Females 61.87% more than males 19 percentage 92.3% soft lenses, 7.7% hard lenses (including RGP), according 16 Pseudomonas aeruginosa , Staphylococcus spp., Serratia marcescens three isolated from samples Overall, sensitive fluoroquinolones aminoglycosides, especially ciprofloxacin gentamicin respectively, resistant against penicillin cephalosporins cefazolin chloramphenicol. Almost all responded well therapy, some exceptions needed surgical interventions. Conclusion Antibiotics efficient treating almost they appropriately chosen based on germs every region sensitivity them. In regard, germ lens-associated over world fully ciprofloxacin. Because results about like gentamicin, vancomycin, chloramphenicol Middle East region, vitro clinical suggested.